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Green tea prevents cancer
Cancer mortality statistics on Japanese people indicate that th death rate
from cancer is significantly lower, for both men and women, i Shizuoka
Prefecture. This fact stimulated our interest in cancer preventio and led
us to calculate the death rate (Standardized Mortality Ratio) b cancer
type for every city, town and village in Shizuoka Prefecture. Based on
these death ratio statistics, we created a cancer distribution map of the
Prefecture and examined it in detail for trends. We found that areas devoted
to green tea production in the central and western regions of Shizuoka
Prefecture exhibit a significantly lower death rate for all types of cancer
in general and for gastrointestinal cancers such as stomach, esophagus
and liver cancer in particular.We then made a survey to see how the residents
of the green tea producing regions, which have such low cancer death rates,
drink their tea. The results showed that those who live in areas where
green tea is the staple crop tend to drink it daily in rather strong concentrations
by frequently refreshing the tea leaves in their pots. From these results
we theorized that green tea must be connected in some way with cancer prevention,
and we decided to continue our research with animal experiments.
Mice were first inoculated with cancer cells and then studied for the growth
of malignancies. One group was given an extract of green tea while another
control group was not given such an extract. Comparison of the two groups
showed a marked reduction in the growth of tumors among the receiving green
tea.In further joint research with Prof. Shu-Jun Cheng of the Cancer Institute,
Chinese Academy of Medical Science (Beijing),mice were given substances
which, when transformed in the body to cancer-causing chemicals, generate
carcinoma in both the esophagus and forestomach. The researchers then proceeded
to check if green tea has the ability to inhibit the development of these
cancers. Administration of green tea extract did indeed reduce the incidence
of cancer to less than 50% .In addition, research at the National Cancer
Institute (Tsukiji, Tokyo) has demonstrated that administration of catechin
(the main component of green tea tannin) to mice previously given chemicals
that induce duodinal cancer can also significantly lower the incidence
of cancer. Green tea and its component catechin have, therefore, been shown
to reduce the growth as well as the actual generation of cancer.
From our prevlous epldemiologlcal research we can estlmate that the inhabitants
of the midwestern region of Shizuoka Prefecture, where green tea is the
staple product and the main beverage, consume as much as 1.0 1.sg of crude
green tea catechins daily in their green tea. This strongly suggests that
green tea catechin plays a role in their low SMR (Standardized Mortality
Ratio) for stomach cancer.
We do not yet fully understand the mechanism underlying the generation
of cancer, but it involves at least the following two stages. This is called
the "two-stage theory of cancer development., A substance capable
of causing mutations (initiator) first damages DNA in the cell and renders
it subject to cancer (initiation). This condition then remains unchanged
for some time until another substance, which activates cancer (promoter),leads
to the actual growth of a malignancy (promotion). It is clear from recent
research that extract of green tea and catechin can markedly inhibit both
stages of development.
Even though these results have been gained from animal studies or pure
laboratory tests, we think it highly significant that green tea and its
component catechin have the ability to prevent cancer. When taken together
with the survey that indicates a striking reduction in the cancer death
rate in the tea producing regions where the residents are accustomed to
drinking quite strong tea by frequent changes of tea leaves, they support
the conclusion that green tea may also be a factor in the prevention of
human cancer.
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